In Silico Identification of Flavonoids from Corriandrum sativum Seeds against Coronavirus Covid-19 Main Protease

Molecular docking analysis is routinely used in modern drug research to understand and predict the relationship between a molecule target protein from microbe. The entry replication of pathogens host cells can be prevented by drugs identified this way. coronavirus disease associated with SARS-CoV-2, COVID-19, has become today's most infectious lethal pandemic world. Burgeoning absence any particular vaccine or therapeutic agent against SARS-CoV-2.The situation urges need for appropriate medications treat patients infected virus. Consequently, study focus on evaluate potential flavonoids present Corriandrum sativum seeds that could serve as suitable remedies COVID19.We analyzed binding affinity four were screened Mpro SARS-CoV-2 PyRx Virtual Screening tool also results are validated Lig-Plot Plus. Lopinavir shows -8.3 Kcal/mol exhibit stable, strong interaction active site COVID19 main protease. Besides flavonoids, Rutin found have highest compared protease, followed Chlorogenic acid, Quercetin Caffeic acid. concludes integrant potentiality acting inhibitor protease enzyme. Further, characterization amino acid residues comprising viral nature hydrogen bonding involved ligand receptor significant findings MPro at sites responsible virus pathogenicity. vivo experiments prove utility compounds further use making anti-SARS-CoV-2 product near future.
 Keywords: seeds,Novel Coronavirus, SARS-CoV2, Protease, Docking.